BPC 157 (body protection compound -157) is a 15-amino acid pentapeptide.The amino acid sequence in BPC157 is similar to that in human BPC.Human stomach BPC exists in gastric juice.Experiments showed that BPC 157 enhanced wound healing, including tendon wounds, such as the transected Achilles tendon in rats.The aim of this study was to investigate the possible mechanisms by which BPC 157 May be used to accelerate the healing process of injured tendons.The study used two groups of tendon explants, one cultured in a medium containing BPC 157 and the other without BPC 157.The cultures were then examined for tendon fibroblast growth.This growth indicates tendon regeneration.The results showed that compared with the culture lacking BPC 157, the growth of foreign and domestic explants in the culture containing BPC 157 was significantly accelerated.In addition, MTT assays did show that BPC 157 did not directly affect cell proliferation.Rat Achilles tendon culture.However, the results also showed that BPC 157 significantly increased cell survival under oxidative stress.In addition, Transwell filter migration assays showed that BPC 157 significantly increased fibroblast migration in vitro in a dose-dependent manner.In addition, BPC 157 accelerated the dispersion of fibroblasts in culture dishes in a dose-dependent manner.