Basic Information of PEG MGF (Pegylated Mechano Growth Factor)
Product Name: PEG-MGF
Synonyms: Pegylated MGF, PEG IGF-1 Ec
Molecular Formula: C121H200N42O39
Molecular Weight: 2888.16
CAS number: 108174-48-7
Growth hormone helps release insulin-like growth factor. One of the variants of insulin-like growth factor is MGF, better known as mechano growth factor. In the past, you had to depend on your body to produce IGF or MGF naturally, but not anymore. Now that scientists have been able to isolate and reproduce these peptide chains, bodybuilders and athletes can recover faster and increase hypertrophy like never before.
PEG-MGF, or PEGylated Mechano Growth Factor, is a new and innovative form of the IGF produced by a frame shift if the IGF gene, namely Mechano Growth Factor (MGF), which is PEGylated to improve stability that outperforms natural MGF many times over. MGF is a splice variant of the IGF gene which increases stem cell count in the muscle and allows for muscle fibers to fuse and mature. This is a process required for growth of adult muscle. Natural MGF is made locally and does not travel into the bloodstream. Synthetic MGF is water based and when administered intramuscularly, travels into the bloodstream. MGF is only stable in the blood stream for only a few minutes. Research has shown that PEG-MGF helps increase the muscle stem cell count, so that more may fuse and become part of adult muscle cells.
In fact, PEG-MGF (Pegylated Mechano Growth Factor) is the best variant of IGF on the market today when it comes to site growth. It leads to an increase in the muscle cells necessary for adult muscles to continue growth beyond their genetic limit. Like other forms of IGF-1, PEG-MGF (also known as IGF-1ec) creates new muscle cells and stimulates muscle growth by promoting nitrogen retention and increasing protein synthesis.
MGF vs PEG MGF
Base MGF which is produced in liver and secreted into the blood stream, only lasts for about 5-7 minutes before it breaks down. This is the regular “base” MGF version that’s not widely used due to the short half-life. The scientists add the additive polyethylene glycol to the MGF Chain in order to give it a half-life of several days. This modified version MGF that we call it PEG-MGF.
What is the Pegylation of Mechano Growth Factor?
PEGylation is the act of attaching a Polyethylene glycol (PEG) structure to another larger molecule (in this case, MGF). The PEG acts as a protective coating and the theory here is that this will allow the MGF to be carried through the blood stream without being broken down. Neurological research has shown that utilizing PEGylated MGF resulted in a longer more stable acting version of the MGF peptide in serum/blood.
The Effects of Pegylated MGF
Mechano Growth Factor (MGF) exhibits local effects in skeletal muscle and without cannot travel through the body without modification. When synthetic Mechano Growth Factor (MGF) is introduced intramuscularly, so it goes into the blood stream, and then it only remains stable in the blood stream for a few minutes. Biologically produced MGF is made locally and does not enter the bloodstream. It is also short acting so stability is not an issue. By PEGylating the Mechano Growth Factor (MGF) it is almost as efficient as local produced Mechano Growth Factor (MGF) when used intramuscularly. This is accomplished by surrounding part of the peptide with a structure of polyethylene glycol, which can be attached to a protein molecule. The polyethylene glycol groups protect the peptide but do not surround it completely. The active sites of the peptide are still free to do their biological function. In this case the shell is a negative charged shield against positively charged compounds that would affect the protein.