IGF-1 LR3 peptide is a synthetic protein and lengthened analogue of human insulin-like growth factor 1 (IGF-1). IGF-1 LR3 peptide is originally known as long arginine 3-IGF-1, and abbreviated as or LR3-IGF-1. It differs from native IGF-1 in that it possesses an arginine instead of a glutamic acid at the third position in its amino acid sequence (“arginine 3”), and also has an additional 13 amino acids at its N-terminus (MFPAMPLLSLFVN) (“long”), for a total of 83 amino acids (relative to the 70 of IGF-1).
The consequences of these modifications are that IGF-1 LR3 retains the pharmacological activity of IGF-1 as an agonist of the IGF-1 receptor, has very low affinity for the insulin-like growth factor-binding proteins (IGFBPs), and has improved metabolic stability. As a result, it is approximately three times more potent than IGF-1, and possesses a significantly longer half-life of about 20–30 hours (relative to IGF-1’s half-life of about 12–15 hours).
Amino Acid Sequence: MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA
Molecular Formula: C400H625N111O115S9
Molecular Weight: 9117.5g/mol
PubChem CID: N/A
CAS NO.: 946870-92-4
Effects and Function of IGF-1 LR3 Peptide:
IGF-1 is a key protein in the formation of protein synthesis. The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Similar to insulin on a molecular level, this peptide mainly affects bone growth, muscle growth, and muscle repair. When working together, they can help your body create new muscle fibers and increase nitrogen retention. IGF-1 Long R3 is known to go well together with HGH treatment. Human growth hormone affects reproduction, regeneration, regulating cell growth, bone healing and cutting fat. The effects of HGH are compounded when used together with IGF-1 Long R3.
IGF1-LR3 has been used for anti-aging and longevity research many years ago. Research in cows and pigs indicates that IGF-1 LR3 administration may be an effective solution for offsetting the effects of cellular aging. This research reveals that IGF-1 administration can prolong life and reduce disability. Ongoing research in mice seeks to determine if IGF-1 LR3 might be useful in preventing progression of a wide range of conditions such as dementia, muscle atrophy, and kidney disease. IGF-1 LR3 promotes tissue repair and maintenance through the body, making it a protective molecule against cell damage and the effects of aging.
Usage of IGF-1 LR3 Peptide:
IGF-1 LR3 (Insulin-like Growth Factor) typically comes in a 1 mg vial. It has a white powder-like appearance and must be reconstituted prior to use with sterile bacteriostatic water for injection.
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