What is CJC-1295?
Mod GRF 1-29 is a peptide hormone that, signals the release of endogenously manufactured Human Growth Hormone from the pituitary gland as opposed to administering exogenous synthetic HGH through injection. It must be made clear that it is not Human Growth Hormone itself, but that it causes a pulsatile release of endogenously manufactured Human Growth Hormone.
Overview and History of CJC-1295
Modified GRF 1-29 is also known as Mod GRF 1-29, but the more common one is CJC-1295 without DAC. However, the appropriate terminology is its original name and classification: quadruple-substituted GRF (1-29). Before going into any further discussion, it is necessary to clarify the confusion about the nomenclature and nomenclature of this particular substance, because most drug groups and individuals wishing to use this substance will undoubtedly become very confused when reading and studying the product. Especially when purchasing later (some vendors list all names while others list only one). The name Mod GRF 1-29 was originally coined by a researcher named Dat Btrue, who coined the term in this online publication on the substance. Because of the popularity of his articles, the new name can easily be widely adopted by readers, and the common use of the name spreads from there. However, the most common name for this substance may be CJC-1295 without DAC. The importance of understanding these differences lies in the history of matter and its structure.
Mod GRF 1-29 belongs to a class of peptides called HGH (human growth hormone) secretagogues. It is an improved derivative of the existing growth hormone releasing hormone (GHRH) derivatives. GHRH is a peptide hormone produced by human body. Therefore, it can be more appropriately referred to as the second generation derivative of GHRH. Modify GHRH to produce so-called growth hormone releasing factor (GRF) 1-29. Then further modify GRF 1-29 to create Mod GRF 1-29. In this regard, the nomenclature of derivative evolution should be self-evident. GRF 1-29 is also known by its trade name Sermorelin (Mod GRF 1-29 is its derivative).
Chemical properties of CJC-1295
Protein/peptide is a chain of amino acids linked in a specific unique sequence. Protein, depending on how many amino acids it consists of, will be shown as one of three structural types: the main protein structure, which is only a long-chain amino acid, the secondary protein structure is a folded protein structure, similar to the folded sheet, the tertiary protein structure, which is a complex protein folding, similar to the entangled yarn ball, and finally the Quaternary protein structure, which is several. A class of interconnected tertiary proteins. The significance of this in many other protein hormones, such as human growth hormone (HGH), insulin, luteinizing hormone (LH), Mod GRF 1-29 (CJC-1295 without DAC), lies in the various parts of the protein. Structures promote different tasks in the body by binding and activating different receptors. The shape of peptide hormones and their different subfractions allow stronger binding affinity or weaker binding affinity.
Growth hormone releasing hormone (GHRH) is an endogenous GHRH secreted by the arcuate nucleus of the hypothalamus, which is 44 amino acids long. However, only the first 29 amino acids of the protein were found to bind to receptors on the pituitary gland with the same structure as the complete 44 amino acids. The first 29 amino acids in the protein structure are then separated and called GRF 1-29, but the problem with this derivative of GHRH is that it is rapidly metabolized by enzymes and removed from the body. The half-life of GRF 1-29 is less than 10 minutes, only 5 minutes. This is clearly not enough to ensure the maximum sustained release of HGH from the pituitary gland, because studies have shown that the full potential of the pituitary HGH pulse takes at least 30 minutes, because the level of HGH is much higher. Subcutaneous application of GHRH analogues was observed for 15-30 minutes.
Therefore, the solution to this problem is to modify GRF 1-29 by replacing various amino acids in its structure with other amino acids, which will provide greater resistance to enzymatic decomposition and cleavage. Many modified analogues were developed, and Mod GRF 1-29 (CJC-1295 without DAC) was chosen as the final choice, which proved the most promising effect. Mod GRF 1-29 is a modification of GRF 1-29, especially in amino acids #2, #8, #15 and #27. The result is that the half-life is extended to at least 30 minutes.
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