Myostatin (GDF-8) is a member of the transforming growth factor-beta (TFF-beta) superfamily, which express well in skeletal muscle. Loss of myostatin function leads to skeletal muscle mass. double. Scientist used Myostatin-deficient as models to study muscle-skeletal interactions. and here we review the bone phenotype associated with changes in the myostatin signaling pathway. Since we know that myostatin is a key regulator of proliferation and differentiation of mesenchymal stem cells. And the body fat reduces as lacking myostatin gene, and generally increases in bone density and strength.

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