Peptides and proteins is also different in functional distinctions. Polypeptides are often biologically inactive and proteins are biologically active. Polypeptides are generally inactive ( for example, polypeptides produced by digestion of proteins in the stomach and small intestine), and with a very small number of active (such as vasopressin is a peptide hormone). Compared to proteins, polypeptides have a small molecular weight, no spatial structure, and are generally inactive. The protein has a large molecular weight, with a spatial structure, and is active. (the activity decreases or disappears after degeneration, and the activity disappears is called inactivation)

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