Peptides Transformation
Summary The sulfonamide moiety is introduced as a potential transitional isostere for hydrolysis of the amide bond.Subsequently, the increased acidity of the sulfonamide N-H compared to the conventional amide N-H…
peptides-and-proteins
The peptide-amide bond is the central recurring structural element of peptides and proteins.
Summary The sulfonamide moiety is introduced as a potential transitional isostere for hydrolysis of the amide bond.Subsequently, the increased acidity of the sulfonamide N-H compared to the conventional amide N-H…