Peptides Transformation
Summary The sulfonamide moiety is introduced as a potential transitional isostere for hydrolysis of the amide bond.Subsequently, the increased acidity of the sulfonamide N-H compared to the conventional amide N-H…
peptides-transformation
Transformation of a peptide – naturally consisting of αamino acid residuesa sequence in which each amide is replaced.
Summary The sulfonamide moiety is introduced as a potential transitional isostere for hydrolysis of the amide bond.Subsequently, the increased acidity of the sulfonamide N-H compared to the conventional amide N-H…