Aicar peptide review

Aicar, also named AICA ribonucleotide. Its Sequence is 5-Aminoimidazole-4-carboxamide ribonucleotide. Aicar, also known as ZMP, is an intermediate in the generation of inosine monophosphate. Aicar is an analog of adenosine monophosphate (AMP). And it is capable of stimulating AMP-dependent protein kinase (AMPK) activity. Doctors have already used Aicar clinically to treat and protect against cardiac ischemic injury. In the 1980s, doctors have already used the drug as a method to preserve blood flow to the heart during surgery.

CAS Number: 3031-94-5

Chemical formula: C9H15N4O8P

Molecular Weight: 338.211

Appearance: Sterile filtered white lyophilized (freeze-dried) powder

AA Sequence: 5-Aminoimidazole-4-carboxamide ribonucleotide

Currently, it was shown that Aicar as a potential treatment for diabetes by increasing the metabolic activity of tissues by changing the physical composition of muscle. AICAR (commonly under the name Acadesine) is an analog of adenosine. It enters cardiac cells to inhibit adenosine kinase and adenosine deaminase. It enhances the rate of nucleotide re-synthesis increasing adenosine generation from adenosine monophosphate only during conditions of myocardial ischemia. In cardiac myocytes, AICA-riboside is phosphorylated to AICA-ribotide (ZMP) to activate AMPK without changing the levels of the nucleotides. ZMP is able to enter the de novo synthesis pathway for adenosine synthesis to inhibit adenosine deaminase causing an increase in ATP levels and adenosine levels.

Medical use

A brief period of coronary arterial occlusion followed by reperfusion prior to prolonged ischemia is known as preconditioning. It has been shown that this is protective. Preconditioning preceded myocardial infarction, may delay cell death and allow for greater salvage of myocardium through reperfusion therapy. AICAR has been shown to precondition the heart shortly before or during ischemia. AICAR triggers a preconditioned anti-inflammatory state by increasing NO production from endothelial nitric oxide synthase. When AICAR is given 24 hours prior to reperfusion, it prevents post ischemic leukocyte-endothelial cell adhesive interactions with increased NO production. AICAR-dependent preconditioning is also mediated by an ATP-sensitive potassium channel and hemeoxygenase-dependent mechanism. It increases AMPK-dependent recruitment of ATP-sensitive K channels to the sarcolemma causing the action potential duration to shorten, and preventing calcium overload during reperfusion. The decrease in calcium overload prevents inflammation activation by ROS. AICAR also increases AMPK-dependent glucose uptake through translocation of GLUT-4 which is beneficial for the heart during post-ischemic reperfusion. The increase in glucose during AICAR preconditioning lengthens the period for preconditioning up to 2 hours in rabbits and 40 minutes in humans undergoing coronary ligation. As a result, AICAR reduces the frequency and size of myocardial infarcts up to 25% in humans allowing improved blood flow to the heart. As well, the treatment has been shown to decrease the risk of an early death and improve recovery after surgery from an ischemic injury.

Where to buy Aicar?

Giant is an online store which offers global customers with all kinds of generic peptides, research peptides and cosmetic peptides and rHGH 191 AA, especially for United States, European and Australian customers. Giant Lab is specializing in being a United States peptide supplier, which has 2 warehouses in Europe, with a Hongkong Based Peptides Company. Giant Lab’s products have been successfully sold to Europe countries, America, Asia, Oceania and other worldwide area, including pharmaceutical companies, biotechnology companies, universities and other research institutions. Giant Lab does worldwide shipment and we guarantee 100% shipment for most customers. With many years of experience in the field of peptide manufacturing, Giant Lab always shows the most professional service to all customers. You can feel much better when you shop there. Giant Lab is proud of providing customers with good quality product and super shipping service.

Please note that all peptides in online store are only for laboratory research purpose, not for human consumption. Get more customers’ reviews from the anabolicsteroidforums Forum. If you have any questions or inquiry, please feel free to contact the knowledgeable and experienced Giant Lab team:

For more info about Aicar, you can also read:

Aicar Buy

What’s Aicar and its Medical use?

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