BPC-157 is a peptide fragment containing 15 amino acid residues separated from gastric juice. As a new type of cell protective agent, it is not only have obvious protective effect on the digestive tract mucosa, liver and pancreas injury, but also can promote the healing of burns, CO2 laser damage, promote tendon healing, also can inhibit inflammatory reaction, such as Parkinsonism and antidepressant. In early times, laboratory confirmed the BPC – 157 can effectively promote the healing of miniature pig skin cut, and verified the BPC – 157 can adjust human umbilical vein endothelial cells (human umbilical vein endothelial cells and HUVEC) raised colonization, migration, and other functions, but its specific molecular mechanisms regulating cell function is still not clear. Research shows that BPC-157 can promote the expression of intestinal epithelial cells’ immediate early genes, the Egr-1. Egr-1 rapidly inducts the production of cytokines and growth factors, and by promoting wound granulation tissue and the formation of collagen in the extracellular matrix to promote wound healing effect. Studies have confirmed that under the condition of H2O2 stress, the BPC – 157 can significantly increase the survival rate of cells, can obviously promote vitro growth and migration ability of the Achilles tendon fiber cells. Western print results showed that phosphorylation level of FAK (BPC and pile (paxillin) is corresponding to the addition of the usage of BPC-157, and suggests that the BPC – 157 may regulate tendon fibroblasts in vitro migration ability by activating FAK- paxillin pathways.
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