In addition, Hexarelin releases more GH than does growth hormone-releasing hormone (GHRH) in humans and produces synergistic effects on GH release in combination with GHRH, resulting in “massive” increases in plasma GH levels even with only low doses of Hexarelin. What’s more, likely due to increases in sex steroid levels, puberty has also been found to significantly augment the GH-elevating actions of Hexarelin in humans. Hexarelin reached phase II clinical trials for the treatment of growth hormone deficiency and congestive heart failure but did not complete development and was never marketed.

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Hexarelin is a synthetic growth hormone secretagogue made from six amino acids. With the amino acid sequence: His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2, Hexarelin is one of several synthetic met-enkephalin analogs that include unnatural D-amino…

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