Hexarelin is a synthetic growth hormone secretagogue made from six amino acids. With the amino acid sequence: His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2, Hexarelin is one of several synthetic met-enkephalin analogs that include unnatural D-amino acids. It was derived from GHRP-6. It contains powerful growth hormone releasing properties in the human body. Furthermore, Hexarelin also know as examorelin, it’s a potent, synthetic, peptidic, orally-active, centrally-penetrant, and highly selective agonist of the ghrelin/growth hormone secretagogue receptor and a growth hormone secretagogue which was developed by Mediolanum Farmaceutici.
History and Scientific Research:
Hexarelin substantially and dose-dependently increases plasma levels of growth hormone (GH) in animals and humans. Hexarelin is considered as the strongest, among the small group of peptides that trigger growth hormone release. Because based on a large amount of research, Hexarelin isn’t readily degraded by proteolytic enzymes and therefore ensures a growth hormone mimicking effect that lasts longer. After the administration of Hexarelin peptide, a major hike in the levels of naturally produced cortisol and prolactin can be noticed too. The administration of this peptide is suggested through the subcutaneous route. This dose of Hexarelin is supposed to be maintained for a year and a half. The dose is supposed to be distributed into 25-50mcg for 1-5 times in a day.
The functionality of Hexarelin:
In addition, Hexarelin peptide releases more GH than does growth hormone-releasing hormone (GHRH) in humans and produces synergistic effects on GH release in combination with GHRH, resulting in “massive” increases in plasma GH levels even with only low doses of Hexarelin. What’s more, likely due to increases in sex steroid levels, puberty has also been found to significantly augment the GH-elevating actions of Hexarelin in humans. Hexarelin reached phase II clinical trials for the treatment of growth hormone deficiency and congestive heart failure but did not complete development and was never marketed.
Hexarelin in studies over a certain period has shown that it reduces visceral fat. Hexarelin (Hexarelin Acetate) like other Growth Hormone Releasing Peptides is most effective synergistically when administered with GHRH such as Sermorelin or Modified GRF 1-29. The increase of circulating GH through Hexarelin use causes levels of Insulin-Like Growth Factor (IGF-1) to rise in the liver. IGF-1 is the prime cause of muscle growth in response to GH stimulation. Users of IGF-1 typically experience increased strength and muscle mass, as well as a very pronounced fat loss. Growth hormone secretion also increases appetite and causes increased lean muscle growth.
Hexarelin has shown that it is highly stimulated at 30 minutes after being induced by rapid and sustained GH secretion. The pituitary gland produces GH in the brain, in children this hormone helps them to grow and in adults it helps to maintain muscle and burn fat. In one sixteen-week study, it has been shown that GH levels return to normal after stopping use after four weeks.
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