Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is an anxiolytic peptide, the analogue of the immunomodulatory peptide tuftsin. It was developed by the Institute of Molecular Genetics of the Russian Academy of Sciences. Due to its anxiolytic effect, it is useful for the treatment of generalized anxiety disorder (GAD) and depression. Its action is similar to that of mild benzodiazepins but without the sedative effects. As a selective anxiolytic with a nootropic component, Selank can be used as treatment of depression, fear and general anxiety. It also reduces phsychic tension. This neuropeptide has passed all phases of clinical trials and is now being prepared for registration and mass production.
Selank peptide is closely related to Semax, a hexapeptide previously invented by the same institute. Some consider Selank to be a more efficient alternative to Semax – a drug currently approved for use in Russia and Ukraine. Both Selank and Semax seem to be less known in the western countries, due to the conflict of interest and subsequently lack of marketing efforts from the “big pharma” industry.
In research studies conducted on both animal and human test subjects, scientists studying Selank have observed profound anxiolytic (anti-anxiety) and antidepressant effects. Importantly, these benefits have been observed to occur in subjects without the negative side effects common to benzodiazepine medications, including addictive, sedative, and withdrawal side effects. Moreover, like the natural peptide Tuftsin, Selank has been shown to have immunoprotective effects. Additionally, it also has been observed in studies to improve attention span, enhance learning capacity, and restore exploratory activity in brain-damaged rat test subjects. Further study has similarly shown Selank to restore vital cognitive processes in rats damaged by artificial inhibition. Ultimately, the discovery of and subsequent research into Selank has sparked great interest in the research community due to its fascinating and profound nootropic effects coupled with minimal, if any, negative side effects.
The Benefits of Selank Peptide:
—- Selank influences the monoamine neurotransmitters concentration involved in regulating memory, arousals as well as emotions.
—- The chemical normally maintains neuron integrity in several psychiatric disorders such as schizophrenia, anxiety and depression.
—- Selank induces endorphins metabolism to treat anxiety and has some benefits over conventional benzodiazepines; for instance, it does not have cognitive side effects and sedating effects.
—- People having depression often show a deficiency of 5-hydroxytryptamine (serotonin), which is a monoamine neurotransmitter that supports a positive mood, enhances appetite and regulates the sleep as well as the wake cycle.
—- Selank has revealed antidepressant effects in clinical studies as a result of its relation to the dopamine and serotonin increase.
—- Selank affects the normal balance of Th cell cytokines, through IL-6 (Interleukin-6) modulation of the expression. Interleukin 6 is an interleukin known to act as an anti-inflammatory myokine as well as a pro-inflammatory cytokine. It’s encoded by the IL6 gene in humans.
—- It stimulates your immune response during trauma and infections. Also, this cytokine stimulates osteoclast formation that remodels, repair and maintains bones of your vertebral skeleton.
—- On another side, Selank’s neuroregeneration properties allow the repair or regrowth of cells, cell products or nervous tissues.