Triptorelin also was known as Gonadotropin-releasing hormone (GnRH) is a synthetic peptide that elicits the release of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) as a biological response of the gonadotropin-releasing hormone receptor through its interaction. This peptide is used to increase fertility and as a treatment for hormonally sensitive cancers.
CAS NO. ： 57773-63-4
Synonyms： Triptorelin Acetate, GnRH
Molecular Formula： C64H82N18O13
Molecular Weight： 1311.45
Triptorelin, a decapeptide (pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2), is a gonadotropin-releasing hormone agonist (GnRH agonist) used as the acetate or pamoate salts. Triptorelin raises testosterone levels by causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). Like other GnRH agonists, triptorelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, precocious puberty, estrogen-dependent conditions (such as endometriosis or uterine fibroids), and in assisted reproduction. Triptorelin is marketed under the brand names Decapeptyl (Ipsen) and Diphereline and Gonapeptyl (Ferring Pharmaceuticals). In the United States, it is sold by Watson as Trelstar.In Iran Triptorelin is marketed under the brand name Variopeptyl (Varian Darou Pajooh). In India, Dr. Reddy’s Laboratories has launched recently Triptorelin under the brand name “Pamorelin LA”. During the treatment of prostate cancer it does cause a surge of testosterone (an initial uplevel of testosterone levels), known as a flare effect. In men a reduction of serum testosterone levels into the range normally seen after surgical castration occurs approximately two to four weeks after initiation of therapy.
How The Triptorelin Work?
Triptorelin is typically used to suppress unprompted ovulation, which is a vital factor in vitro fertilization (IVF). Apart from releasing the FSH, the peptide also triggers the release of an oocyte, which as a result increases the chances of pregnancy.
When the peptide fuels the release of Follicle-Stimulating Hormone and Luteinising Hormone from the pituitary glands, it creates an increase in testosterone levels and also increases the sperm count in adult male or eggs in females.
The Results and benefits of Triptorelin:
Triptorelin can be useful in the treatment of congenital adrenal hyperplasia that involves abnormal production of sex steroids, which can cause vomiting, ambiguous genitalia, early pubic hair in childhood, early puberty and delayed puberty, menstrual irregularity, infertility and an enlarged clitoris, among others.
This peptides can manage dependent estrogen disorders like menorrhagia (an abnormal menstrual period in its quantity and duration), endometriosis (growth of uterine tissue outside the uterus), adenomyosis (growth of ectopic endometrial tissue within the myometrium) or uterine fibroids (benign smooth muscle tumors of the uterus).
Triptorelin is a very useful peptide and people who have used it prefer a single dose of 100 mcg in a four months cycle. It is always advised that Triptorelin dosage has to be measured accurately to avoid any excesses. Furthermore, it is vital not to use more than 1 mg in a year.
This is because excess Triptorelin doses can damage the male testes due to hyperstimulation of the pituitary gland.