What is BPC-157?
Molecular Formula: C62H98N16O22
Molecular Weight: 1419.556 g/mol
InChI Key: HEEWEZGQMLZMFE-DGQLYNSISA-N
Chemical Names: Bpc 15; Bpc 157; Booly protection compound 15; Bpc-157; BPC-15; UNII-8ED8NXK95P
BPC 157 (body protection compound -157) is a 15-amino acid pentapeptide.The amino acid sequence in BPC157 is similar to that in human BPC.Human stomach BPC exists in gastric juice.Experiments showed that BPC 157 enhanced wound healing, including tendon wounds, such as the transected Achilles tendon in rats.The aim of this study was to investigate the possible mechanisms by which BPC 157 May be used to accelerate the healing process of injured tendons.The study used two groups of tendon explants, one cultured in a medium containing BPC 157 and the other without BPC 157.The cultures were then examined for tendon fibroblast growth.This growth indicates tendon regeneration.The results showed that compared with the culture lacking BPC 157, the growth of foreign and domestic explants in the culture containing BPC 157 was significantly accelerated.In addition, MTT assays did show that BPC 157 did not directly affect cell proliferation.Rat Achilles tendon culture.However, the results also showed that BPC 157 significantly increased cell survival under oxidative stress.In addition, Transwell filter migration assays showed that BPC 157 significantly increased fibroblast migration in vitro in a dose-dependent manner.In addition, BPC 157 accelerated the dispersion of fibroblasts in culture dishes in a dose-dependent manner.
In addition, fitc-ghostpen cyclic peptide staining demonstrated that BPC157 induced the formation of f-actin in fibroblasts.Similarly, Western blot analysis can detect the production and activation of pilin and FAK protein.Western blot analysis also showed that BPC 157 increased the phosphorylation of pilin and FAK without affecting the amount produced.
Therefore, it was concluded that BPC 157 enhanced in vitro growth and migration of fibroblasts derived from rat tendon explants.In addition, BPC 157 increased the possibility of cell survival under oxidative stress.These effects of BPC157 may be mediated by activation (via phosphorylation) of the fak-pilin pathway of the protein.
Where to buy BPC-157?
You can buy BPC-157 online from the Giant Lab. If you decide to purchase Hexarelin online, you must first understand the laws in your country, as they may vary from person to person. In the United States, such purchases are legal, but are for research purposes only. You cannot legally purchase BPC-157 online for personal use.