GHRP-2 (also known as KP 102 or Pralmorelin) is a synthetic hexapeptide Growth Hormone Releasing Peptide (GHRP), which acts on the hypothalamus and the pituitary gland to release growth hormone with a slight stimulator effect on Prolactin, ACTH and Cortisol levels. GHRP-2 is considered to be a true hGH secretagogue, meaning that it stimulates the body’s own secretion of hGH. Human Growth hormone has been shown in studies to promote lean body mass and reduce adiposity (fat). GHRP2 has demonstrated that it is very effective at stimulating GH production in research test subjects. It has a short half life with peak concentrations occurring around 15 minutes and not longer than 60 minutes after administration.
Molecular formula: C45H55N9O6
Molar Mass: 817.9
CAS number: 158861-67-7
PubChem: CID 6918245
Synonyms: Growth Hormone Releasing Peptide-2; GHRP2; GHRP 2
Describe of GHRP-2:
It’s a peptide that stimulates your body’s growth hormone (also known as somatotropin or human growth hormone) production. It’s one of the most effective and powerful preparations of the GHRP group, excelling in efficiency Ipamorelin and growth hormone-releasing peptide 6 (GHRP-6 or growth hormone-releasing hexapeptide) by approximately 30 per cent.
Its action is typically caused by the hypothalamus and pituitary stimulation, leading to an increased secretion of GH in 7 to 15 times, while the other stimulators of GH, based on the gamma-Aminobutyric acid (GABA or γ-aminobutyric acid) and amino acid level, don’t provide an increase that is more than 2 to 3 times.
The hypophysis (pituitary gland) is an endocrine gland that is roughly the size of a pea. It weighs 0.018 oz (0.5 grams) in the human body. It is located in the centre of the brain, and its function is to regulate the production of hormones of most of the endocrine glands.
The hypothalamus is the portion of the diencephalon (a division of the forebrain), the main centre of the ANS or autonomic nervous system (ANS, which humans don’t control, regulates blood circulation, metabolism organs, reproduction, excretion, digestion as well as respiration), controls sleep cycle, hormone levels and much more.
Hence, the peptide interacts with growth hormone secretagogue receptors (ghrelin receptors) and causes increased appetite.
The Utility of GHRP-2 as a Growth Hormone Secretagogue:
GHRP-2 has been studied extensively for its utility as a growth hormone secretagogue (GHS). Scientists have discovered that the Growth Hormone Releasing Peptide-2 increases the natural production of growth hormone (GH). In the early 90’s, one of the most famous studies was performed and later published in 1997 in the Journal of Endocrinology and Metabolism. This study further exemplifies the theory that growth hormone releasing peptides (including Ipamorelin and GHRP-6) could help hormone deficient adults and children. Ever since these major scientific studies, GHRP-2 has been widely produced. With other scientific labs confirming the results from their studies, GHRP-2 can in fact work for those who lack the ability to make adequate human growth hormone. Results however will differ with the use of GHRP-2 because species respond differently based on the pituitary somatotrophs and the differences in the subtypes of GHRP receptors. In the physiologic system, the actions are blocked by GRF receptors antagonist which acts through a different receptor to that employed by earlier GHRPs.
The preparation has an impact on a number of body functioning aspects providing:
- stimulation of enhanced growth hormone;
- increased power performance;
- increased appetite;
- increase muscle mass;
- lowering cholesterol levels;
- burning fat;
- bones strengthening;
- ensuring an anti-inflammatory effect, improving immunity;
- increasing linear growth in children and adolescents;
- improved skin properties;
- protection of the liver.