AMINO ACID SEQUENCE
R3 IGF1, R3 IGF-1, R3IGF1, R3IGF-1, LONG IGF1, LONG IGF-1, LONG R3 IGF1, LONG R3IGF1, LONG R3 IGF-1, LONG R3IGF-1.
IGF-1 (insulin-like growth factor-1) is a major hormone regulator of state growth. Under normal conditions, growth hormone (GH) binds to receptors in the liver and other tissues, stimulating the synthesis/secretion of IGF-1. In target tissues, type 1 IGF receptors homologous to the insulin receptor are activated by IGF-1, resulting in intracellular signaling, thereby stimulating multiple processes leading to state growth. Part of the metabolism of IGF-1 is to stimulate the uptake of glucose, fatty acids and amino acids, thereby allowing metabolism to support growing tissues.
LR3 is a long-term mimetic of human IGF-1, specifically designed and manufactured for mammalian cell culture, supporting large-scale production of recombinant biopharmaceuticals.
Recombinant human LR3 insulin-like growth factor-1 is produced in E. E. coli is a single-stranded non-glycosyl polypeptide chain consisting of 83 amino acids with a molecular weight of 9.1 kDa.
What is IGF-1 LR3?
Long[R3] insulin-like growth factor-I (IGF-1 Long[R3] ) is a Human Recombinant, single, non-glycosylated, polypeptide chain containing 83 amino acids. It is an analog of human IGF-1 comprising the complete human IGF-1 sequence with the substitution of an Arginine (Arg or R) for the Glutamic Acid (Glu or E) at position 3 (hence R3), and a 13 amino acid extension peptide at the N-terminus. IGF-1 LR3 comprises a family of peptides (protiens) that play important roles in mammalian growth and development. IGF1 LR3 is also known as Long R3 IGF-1 or Insulin-Like Growth Factor-I Long Arg3. The Long R3 IGF-1 version is significantly more potent than regular IGF-1.
This analog has been engineered with the express purpose of increasing biological activity. IGF-1 Long[R3] is significantly more potent than IGF-1 in vitro and in vivo. The enhanced potency is due to the markedly decreased binding of IGF-1 Long[R3] to all IGF binding proteins. These binding proteins normally inhibit the biological actions of IGFs. IGF-1 stands for insulin-like growth factor. It is a natural substance that is produced in the human body and is at its highest natural levels during puberty. During puberty IGF-1 is the most responsible for the natural muscle growth that occurs during these few years. There are many different things that IGF-1 does in the human body. The LR3 is a long-term analog of human IGF-1, specifically designed and manufactured for mammalian cell culture to support large-scale manufacturing of recombinant biopharmaceuticals.
Early studies showed that growth hormone did not directly stimulate the incorporation of sulfate into cartilage, but rather acted through a serum factor, termed ‘sulfation factor,’ which later became known as ‘somatomedin’. IGF-1 LR3 is the primary protein involved in responses of cells to growth hormone (GH): that is, IGF-I is produced in response to GH and then induces cellular activities. One such example is muscle growth or hyperplasia. This compound also makes the human body more sensitive to insulin. It is the most potent growth factor found in the human body. IGF-1 causes muscle cell hyperplasia, which is an actual splitting and forming of new muscle cells. The most effective form of IGF-1 is considered to be IGF-1 LR3. This formula has been chemically altered to avoid binding to proteins in the human body, and to increase the half life, approximately 20-30 hours.
IGF-1 LR3 is unlikely to cause the allergic reaction, and almost no side effects. It is for only a few individuals, if they appear.
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