Ipamorelin is a peptide agonist of the Ghrelin Hormone Secretagogue Receptor (GHSR), which significantly increases plasma growth hormone (GH) levels in humans. The pharmaceutical company Novo Nordisk originally developed this peptide, but now it has been discontinued because of its low effectiveness. It was tended to be used for the stimulation of growth of children with growth retardation.
Molecular formula: C38H49N9O5
Molecular Weight: 711.868g/mol
CAS number: 170851-70-4
PubChem CID: 9831659
How does it work?
Ipamorelin binds of GHSR due to its agonist property to activate it in the search for a biological response. This receptor is located in the hypothalamic ventromedial nucleus of the brain and it is in charge of the production of energy homeostasis (that enhance the regulation of caloric intake by signaling the brain to regulate the sensation of hunger) and the regulation of body weight.
Results and Benefits of Ipamorelin:
- Unlike other peptides, Ipamorelin doesn’t affect prolactin (PRL), a protein that is secreted by the hypophysis (pituitary gland) and in response to nursing, ovulation, estrogen treatment, mating, as well as eating. It enables milk production in mammals as well as regulates the immune system plus pancreatic development.
- There are no adverse effects that have been reported in FSH (Follicle-Stimulating Hormone) as in LH (Luteinizing hormone). In women, Follicle-Stimulating Hormone and Luteinizing hormone cause ovulation release through ovaries stimulation, while in men, they contribute to the production of testosterone and sperm through testicles stimulation.
- No effect has ever been reported on THS (Thyroid-Stimulating Hormone) during Ipamorelin use. This is important since Thyroid-Stimulating Hormone plays a significant role in the metabolism stimulation of nearly every tissue in your body. It plays an important role in regulating the endocrine function of a thyroid gland that stabilises your thyroid hormone level and avoids an excessive production, which can end up causing hyperthyroidism condition as well deficiency of thyroid hormone resulting in a disorder known as hypothyroidism.
- Ipamorelin doesn’t stimulate ACTH (Adrenocorticotropic Hormone) secretion that is produced on your anterior pituitary gland. Biological stress stimulates Adrenocorticotropic Hormone and can increase cortisol production (depressing your immune system). Adrenal insufficiency (lack of production of sufficient amounts of steroid hormones such as cortisol) can be the cause of elevated levels of ACTH.
- No cortisol affections caused by this peptide have been reported. As aforementioned, cortisol, which is in the glucocorticoid class of hormones, is responsible for maintaining an adequate insulin balance by keeping optimal sugar levels in your blood plus the use of fat and sugar to obtain energy. Also, it contributes to control as well as respond to stress (people who are suffering from depression and chronic stress have shown high cortisol levels).
- Cortisol regulates your BP (avoiding alterations to your arterial function, memory, sexual performance, vision, kidney as well as your heart) and your immune system.
Ipamorelin Is Neglected in Research:
Though ipamorelin does not have orphan-drug status at this time, it is still a neglected drug in research settings. Despite promising early studies, interest in ipamorelin has waned following the decision not to pursue it as a treatment for post-operative ileus. Ipamorelin has a number of benefits to offer, not just as a therapeutic, but as a tool for better understanding a number of disease states and their physiologic impacts. Ipamorelin will likely be of interest in research again, once someone jump-starts the field with new data and cutting-edge insight into the benefits of this unique peptide.