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DSIP(Delta Sleep Inducing Peptide)

13.00$ 10.00$

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DSIP(Delta Sleep Inducing Peptide)

13.00$ 10.00$

Delta sleep-inducing peptide, abbreviated DSIP, is a neuropeptide that when infused into the mesodiencephalic ventricle of recipient rabbits induces spindle and delta EEG activity and reduced motor activities.Its aminoacid sequence is Тrр-Аlа-Gly-Gly-Asp-Ala-Ser-Gly-Glu. However, the gene is unknown[citation needed], raising serious questions regarding the actual existence of this peptide in nature.The products we offer are intended for laboratory research use only.The Products we sold on our store are not been used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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Description

DSIP(Delta Sleep Inducing Peptide)

Warning:
THIS PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY .IT IS FOR RESEARCH USE ONLY, NOT FOR HUMAN CONSUMPTION!

Basic Information

DSIP (Delta Sleep Inducing Peptide)
Quantity: 5mg
Purity: >99% by HPLC
CAS NO.:  62568-57-4
Molecular Formula: C35H49N10O18
Molecular Weight: 928.8
Appearance: Sterile filtered white lyophilized (freeze-dried) powder
AA Sequence:  Тrр-Аlа-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to settle the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20°C. Further dilutions should be made in appropriate buffered solutions.
Storage: This lyophilized preparation is stable at room temperature when garded from light, but should be kept at -20°C for long term storage, preferably with dessicant. Upon reconstitution, the preparation is stable when stored at 2-8°C. For maximum stability, apportion the reconstituted preparation into working aliquots and store at -20°C. Avoid repeat freeze/thaw cycles.

More Information

DSIP(Delta Sleep Inducing Peptide) is an amphiphilic peptide of molecular weight 850 daltons with the amino acid motif:N-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-C

It has been found in both free and bound forms in the hypothalamus, limbic system and pituitary as well as various peripheral organs, tissues and body fluids. In the pituitary it co-localises with many peptide and non-peptide mediators such as corticotropin-like intermediate peptide (CLIP), adrenocorticotrophic hormone (ACTH), melanocyte-stimulating hormone (MSH), thyroid-stimulating hormone (TSH) and melanin concentrating hormone (MCH). It is abundant in the gut secretory cells and in the pancreas where it co-localises with glucagon.

In the brain its action may be mediated by NMDA receptors. In another study Delta sleep-inducing peptide stimulated Acetyltransferase activity through α1 receptors in rats. It is unknown where DSIP is synthesized.

In vitro it has been found to have a low molecular stability with a half life of only 15 minutes due to the action of a specific aminopeptidase-like enzyme. It has been suggested that in the body it complexes with carrier proteins to prevent degradation, or exists as a component of a large precursor molecule,but as yet no structure or gene has been found for this precursor.

Evidence supports the current belief that it is regulated by glucocorticoids.

Gimble et al. suggest that DSIP interacts with components of the MAPK cascade and is homologous to glucocorticoid-induced leucine zipper (GILZ).GILZ can be induced by Dexamethasone. It prevents Raf-1 activation, which inhibits phosphorylation and activation of ERK.Read more about DSIP 

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