Gonadorelin  is secreted in the pituitary portal vein blood flow in the medial bulge . Portal vein blood carries GnRH to the pituitary gland, which contains gonadotropin cells, in which GnRH activates its own receptor, the gonadotropin-releasing hormone receptor (GnRHR), a seven-transmembrane G-protein coupled receptor that stimulates phosphoinositide Beta subtype. Phospholipase C continues to mobilize calcium and protein kinase C. This results in the activation of proteins involved in the synthesis and secretion of gonadotropin LH and FSH. GnRH is proteolytically degraded in a matter of minutes.

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