What is Gonadorelin?
Gonadorelin, also known as gonadotropin releasing hormone (GnRH), is a peptide produced by the hypothalamus in the brain. It is used to detect the presence of luteinizing hormone (LH) and follicle stimulating hormone (FSH) in children and to determine the fertility of adults. Gonadorelin tests how the hypothalamus and pituitary glands work.
GnRH is secreted in the pituitary portal vein blood flow in the medial bulge . Portal vein blood carries GnRH to the pituitary gland, which contains gonadotropin cells, in which GnRH activates its own receptor, the gonadotropin-releasing hormone receptor (GnRHR), a seven-transmembrane G-protein coupled receptor that stimulates phosphoinositide Beta subtype. Phospholipase C continues to mobilize calcium and protein kinase C. This results in the activation of proteins involved in the synthesis and secretion of gonadotropin LH and FSH. GnRH is proteolytically degraded in a matter of minutes.
Molecular formula: C59H83N17O17
Molar Mass: 1302.39
CAS number: 71447-49-9
How does Gonadorelin work?
The pituitary gland is responsible for the release of sex hormones (LH and FSH). In women, LH causes ovulation release by stimulating the ovaries. In men, it helps to produce testosterone by stimulating the testes; in addition, FSH helps sperm production by stimulating the testes. Gonadorelin can also be injected at low doses to determine sufficient yield of LH and FSH, which is useful for diagnosing hormonal disorders to treat them.
This lyophilized preparation is stable at room temperature when garded from light, but should be kept at -20°C for long term storage, preferably with dessicant. Upon reconstitution, the preparation is stable when stored at 2-8°C. For maximum stability, apportion the reconstituted preparation into working aliquots and store at -20°C. Avoid repeat freeze/thaw cycles.