Gonadorelin acetate

What is Gonadorelin?

Gonadorelin, also known as gonadotropin releasing hormone (GnRH), is a peptide produced by the hypothalamus in the brain. It is used to detect the presence of luteinizing hormone (LH) and follicle stimulating hormone (FSH) in children and to determine the fertility of adults. Gonadorelin tests how the hypothalamus and pituitary glands work.


GnRH is secreted in the pituitary portal vein blood flow in the medial bulge . Portal vein blood carries GnRH to the pituitary gland, which contains gonadotropin cells, in which GnRH activates its own receptor, the gonadotropin-releasing hormone receptor (GnRHR), a seven-transmembrane G-protein coupled receptor that stimulates phosphoinositide Beta subtype. Phospholipase C continues to mobilize calcium and protein kinase C. This results in the activation of proteins involved in the synthesis and secretion of gonadotropin LH and FSH. GnRH is proteolytically degraded in a matter of minutes.

Gonadorelin is a gonadotropin-releasing hormone agonist (GnRH agonist) used in reproductive medicine and in the treatment of amenorrhea and hypogonadism. It is also used in veterinary medicine. The drug is a form of endogenous GnRH that is identical in chemical structure. It is administered by injection into blood vessels or fat or as a nasal spray.


Gonadorelin (also known as Gonadorelin Acetate) is a synthetically produced gonadotropin releasing hormone (GnRH). Gonadorelin mainly stimulates the synthesis and release of luteinizing hormone (LH) in the anterior pituitary. The production and release of gonadotropin (FSH) is also increased by gonadotropins, but to a lesser extent. In prepubertal women and some gonadal dysfunction, the FSH response may be greater than the LH response.

Medical uses

Gonadorelin was used as a diagnostic agent for assessing the function of the pituitary gland. It is also used to treat primary hypothalamic amenorrhea, low gonadotropin hypogonadism (such as Kalman syndrome), delayed puberty, cryptorchidism and infertility. Unlike other GnRH analogues, it is not used to inhibit the production of sex hormones.

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