Cosmetic Peptide: Snap-8

Cosmetic Peptide:SNAP-8

INCI name: Acetyl Glutamyl Heptapeptide-1 

Sequence: Acetyl-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2

Molecular formula: C41H70N16O16S

Molecular weight: 1075.16 

SNAP-8 is a mimic of the N-terminal end of SNAP-25 which competes with SNAP-25 for a position in the SNARE complex,thereby modulating its formation.If the SNARE complex is slightly destabilized,the vesicle can not release neurotransmitters efficiently and therefore muscle contraction is attenuated, preventing the formation of lines and wrinkles.

Cause of Facial Wrinkling

One of the most obvious signs of skin aging,that is an increase in facia wrinkles.In addiction,under environmental exposure,this occur over time.Moreover,it is due to certain biochemical,historical,and physical changes.These are other secondary factors that can cause characteristic wrinkles,and facial wrinkles.For instance,muscle  contraction of facial expressions to cause these following,include constant gravitational pull,frequent and constant positional pressure on the facial skin(eg during sleep)or repeated facial movements.Facial aging has a line with changes in collagen conformation,Triple helix, degradation of elastin polypeptides and certain conditions in skin lipid matrix packaging.

How Does SNAP-8 Work?

At their most basic, peptides are cell-communicating agents. SNAP-8 peptide, on the other hand, is considered a neuropeptide – it blocks cell communication instead of encouraging it. Your body naturally produces neuropeptides which decrease as we age. Therefore they target your cells and communicate to your skin how to behave: anything from stimulating collagen production to skin cell regeneration.In a word,SNAP-8’s job is to communicate with your neurotransmitters and cause limited movement in your muscles, preventing the appearance and formation of deep lines.

The Benefits of SNAP-8

– Reduces the depth of wrinkles

Reduce the depth of wrinkles on the face caused by the contraction of muscles of facial expression, especially in the forehead and around the eyes.

– A safer, cheaper, and milder alternative to Botulinum Toxin

Topically targeting the same wrinkle-formation mechanism in a very different way.

– Has been incorporated in cosmetic formulations such as emulsions, gels, sera, etc., where removal of the deep lines or wrinkles in the forehead or around the eyes area is desired.

The synthesis of SNAP-8 involves a final freeze-drying step. Freeze-dried products are commonly obtained as a polymorphous crystalline powder, which means that locally some aggregates and differences in crystal size may appear. This polymorphism is not associated to chemical differences and extensive work performed by the analytical department has ensured the homogeneity of the product. SNAP-8 is presented either as SNAP-8 Powder, an octapeptide in powder form which can be easily dissolved in water, or as SNAP-8 Solution, an aqueous solution containing 0.5 g/L of the powder version. It can be incorporated at the final stage of the manufacturing product, provided the temperature is below 40 degrees Celsius. Taking into consideration the concentration of peptide in SNAP-8 Solution, it is recommended that 3 to 10% of the solution is present in the final formulation in order to obtain significant anti-wrinkle activity.


The most effective way to prevent or minimize peptide degradation is to store the peptide in lyophilized form at -20°C or

preferably at –80°C (if available). If the peptide is in solution, freezethaw cycles should be avoided by freezing individual

aliquots. Exposure to pH>8 should be avoided. However, if it is necessary to dissolve peptides at pH>8, the solutions

should be chilled. Finally, prolonged exposure of lyophilized peptides and solutions (especially at high pH) to atmospheric.

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