Mechano Growth Factor (also known as MGF and IGF-1Ec) is a splice variant of IGF-1 and was only discovered in 1996. MGF is produced locally within the muscles, whereas IGF-1 is manufactured in the liver mediated by Growth Hormone (GH).
Using MGF alone poses two restrictions. The first is its inability to travel through the body to other areas of the body and secondly once secreted by the liver it remains in the bloodstream for about 5-7 minutes before it breaks down.
MGF’s role is to increase stem cell count in the muscle, which stimulates muscle growth and recovery and also increase protein synthesis. It is produced naturally as a result of muscle breakdown from resistance training. Research has shown that MGF can increase the weight of muscle fibre by 20 per cent within two weeks, making it more potent at muscle growth than IGF-1.
Furthermore, research at The Royal Free and University College Medical School in London, UK found that in response to exercise and/or damage, MGF is expressed locally and that it activates the muscle stem cell pool and increases the anabolic effects.
MGF has also been confirmed to have a positive role on bone injury healing in injured white rabbits, where injecting MGF peptide into the injured bone for five days resulted in faster bone healing. Furthermore, increased expression of MGF was detected during the prolonged extension of the Achilles tendons of rats. These experiments confirm the role of MGF as a local tissue repair peptide and indicated that it is responsive to mechanical stimulation.
MGF is up-regulated in damaged and exercising muscle and is likely to stimulate muscle growth since it has been shown to stimulate proliferation of muscle cells and suppress their differentiation. No MGF receptor has been found and it is likely that MGF is a peptide that acts inside the cell itself in order to change the production of additional proteins that influence muscle growth and repair. A single intramuscular injection of a gene producing MGF resulted in a 25% increase in muscle fibre cross sectional area in less than three weeks in a mouse model. MGF can therefore be used as an exercise supplement for athletes and bodybuilders trying to increase strength and muscle mass.
MGF has also been shown to play a neuroprotective role in damaged brain cells and was shown to be present in various brain tissues. In muscle cells, MGF is known to stimulate stem cells to grow and replicate into new muscle fibres. The production of MGF also leads to an upregulation of protein synthesis to build new muscle. Moreover, release of MGF results in the production of IGF-1Ea from the liver, which also works to upregulate protein synthesis to aid in muscle growth and the repair of damaged muscle tissue.
MGF has not been tested for its safety in human clinical trials, but it is naturally found in human muscle and has been shown to be well-tolerated in animal studies at doses up to 10 mcg/kg. Some minor side effects that may occur following MGF injection include facial flushing and nausea. MGF decay has never been measured in humans, but it is estimated to have a very short half-life when administered orally or via injection. The limited half-life means that MGF should be directly injected into multiple points along each muscle once it has been reconstituted in BAC water. Between 100-300 mcg of MGF should be divided between 2-4 muscles each day for best results. It is best to administer the peptide 2 hours after training and at least 2 hours before sleeping to prevent disruption of natural growth hormone production during sleep.
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