What is Peptides?

What is Peptides? Polypeptide is compound in which alpha-amino acids are linked together by peptide bonds .It is also intermediate in protein hydrolysis. A compound obtained by dehydration condensation of two amino acid molecules is called a dipeptide, and analogously, a tripeptide, a tetrapeptide, a pentapeptide, and the like. A compound usually obtained by dehydration condensation of 10 to 100 amino acid molecules is called polypeptide. Peptide introduction A peptide is a compound in which α-amino acids are linked together by peptide bonds, and it is also an intermediate product of protein hydrolysis. Generally, the number of amino acids contained in the peptide is two to nine.According to the number of amino acids in the peptide, the peptide has various different names:A compound obtained by dehydration condensation of two amino acid molecules is called a dipeptide, and similarly, a tripeptide, a tetrapeptide, a pentapeptide or the like is also present up to the nonapeptide. General compounds which are typically dehydrated and condensed from 10 to 100 amino acid molecules are referred to as polypeptides.They have a molecular weight of less than 10,000 Da (Dalton, Dalton) , can pass through a semipermeable membrane and will not be precipitated by trichloroacetic acid and ammonium sulfate. About peptides consisting of 2 to 10 amino acids, It is called an oligopeptide (small molecule peptide);A peptide consisting of 10 to 50 amino acids is called a polypeptide; a peptide consisting of 50 or more amino acids is called a protein, in other words, a protein is sometimes called a polypeptide. Polypeptides, also known as peptides, were discovered in the 20th century. Classification of peptides The polypeptide has two kinds : biologically active polypeptides and artificial synthetic polypeptides. Type of polypeptide 一,Cytokine mimetic peptide 二,Antibacterial active peptide 三,Polypeptide for cardiovascular disease 四,Other pharmaceutical small peptides 五,Diagnostic polypeptide 一,Cytokine mimetic peptide Using receptors of known cytokines from screening of cytokine mimetic peptides from peptide libraries ,has become a hot research topic at domestic and abroad in recent years. Foreign countries have screened a variety of growth factors such as human erythropoietin, human thrombopoietin, human growth hormone, human nerve growth factor and interleukin, the amino acid sequence of these peptidomimetics and their corresponding cytokine amino acids.The amino acid sequences of these peptidomimetics differ from the amino acid sequences of their corresponding cytokines, but have cytokine activity and have the advantage of having a small molecular weight. These cytokine mimetic peptides are in the preclinical or clinical research phase. 二,Antibacterial active peptide When insects are stimulated by the external environment, a large number of cationic polypeptides with antibacterial activity are produced, and more than 100 kinds of antimicrobial peptides have been screened. In vitro and in vivo experiments have confirmed that multiple antimicrobial peptides not only have a strong bactericidal ability but also kill tumor cells. For example, the antimicrobial peptide D screened from silkworms has a good application prospect and can be produced by genetic engineering techniques. here are also a variety of active peptides in snake venom. A 13 amino acid (INKAIAALAKKLL) small peptide is isolated from snake venom, which has strong bactericidal ability against G+ and G-bacteria. 三,Polypeptide for cardiovascular disease Many botanical Chinese medicines have the effects of lowering blood pressure, lowering blood fat, and thrombolytics, and can be used not only as medicines but also as health foods.However, its application is greatly limited due to its undetermined composition. It has been found that many active ingredients are small molecular peptides. For example, the active peptides isolated from soybean processing by Chinese scientists can be directly absorbed through the small intestine, which can prevent and treat blood clots, high blood pressure and high blood fat, and can delay aging and improve the body’s anti-tumor ability.Many small peptides for cardiovascular diseases have also been isolated from plants such as ginseng, tea, and ginkgo leaves. 四,Other pharmaceutical small peptides Small peptide drugs have made some progress in many other fields.For example, Stiernberg et al found that a synthetic peptide (TP508) peptide can promote the regeneration of wound blood vessels and accelerate the healing of deep wounds in the skin. Pfister et al found that a small peptide (RTR) 4 can prevent alkali damage to the infiltration of inflammatory cells in the cornea and inhibit the inflammatory response. Carron et al. demonstrated that the two synthetic peptides screened inhibited bone resorption by osteoclasts. 五,Diagnostic polypeptide The most important use of peptides in diagnostic reagents is as an antigen for detecting viruses such as viruses, cells, mycoplasma, spirochetes, and other parasites such as cysticercosis and trypanosomes. The polypeptide antigen is more specific than natural microorganisms or parasite protein antigens. Moreover, it is easy to prepare, and therefore the detection reagents assembled have low false negative rate and background reaction of the detection antibody, and are easy for clinical application. Currently, antibody detection reagents assembled with polypeptide antigens include: A, B, C, G or hepatic virus, HIV, human cytomegalovirus, herpes simplex virus, rubella virus, Treponema pallidum, cysticercosis, trypan worm, Lyme disease and Rheumatoid and so on. Most of the polypeptide antigens used are obtained from natural protein intra-analytical screening of the corresponding pathogens, and some are novel small peptides screened from peptide libraries. Rear more articals :https://giantlab.net/peptides-production-method/ https://giantlab.net/peptides-storage-method/ https://giantlab.net/active-peptide/ Order Guidance :https://giantlab.net/how-to-order-petides/ Buy Peptides now :https://giantlab.net/peptides/
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