ACE-031, also known as ACVR2B, belongs to the family of protein. ACE-031 is a soluble form of the activin type IIB receptor and is know to bind to myostatin and neutralize its effects. Myostatin is a protein, produced by muscle cells, that inhibits both hypertrophy and hyperplasia of skeletal muscle. ACE-031 also likely has effects on bone metabolism, fat storage, and the health of sperm.
Sequence: Not Available
PubChem SID: 135293965
CAS No.: 1169766-01-1
Synonyms: Ramatercept, ActRIIB-IgG1, ACVR2B/Fc
ACE-031 is a soluble form of the type IIB activin receptor (ACVR2B), which is a potent regulator of muscle growth in vivo. Myostatin, a negative regulator of muscle growth, is bound by ACVR2B and subsequently inactivated. Research in mouse models shows that knocking out the activin receptor boosts mass in all muscle cells. As a result of this connection, ACE-031 has been investigated in several clinical trials as a potential treatment for muscle-wasting diseases like Duchenne muscular dystrophy (DMD). Activin receptors also play important roles in the development of gametocytes, particularly sperm. The receptor is also often found to be inactivated in prostate cancer and is damaged or dysfunctional in several different types of colorectal cancer.
Effects of ACE-031
To further explore the efficacy of Ace-031, a famous pharmaceutical company did a research in 2007. At that point the company only had animal studies to back them up. Several years later, with the continuous improvement of science and technology, they published the results of a human study in 2013, in which 48 healthy women aged from 45-75 had been given a single injection containing 0.02, 0.05, 0.1, 0.3, 1 or 3 mg ACE-031 per kg bodyweight. The substance remained in circulation in the body for a number of weeks: the half-life was 10-15 days.
However, the single injection did lead to muscle growth. The 3-mg/kg dose led to an increase in muscle of volume of 5 percent, it boosted lean body mass by 3 percent just over a kilogram, and seemed to also reduce fat mass. The injection reduced the leptin concentration and boosted that of adiponectin. This would suggest that ACE-031 breaks down fat mass.
In addition, There are various reports and studies proving that the use of ACE-031 drastically increases the muscular growth in animals, specifically in mammals. And those researches was determined that all of the subjects were “healthy” and didn’t have any form of surgery in the past few months.
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