PEG MGF is considered the best variant of Insulin-like Growth Factor (IGF) for local muscle growth on the market. Its ability to stimulate the release of Mechano Growth Factor (MGF) into the system to initiates muscle growth and repair is why it’s so popular with athletes.

PEG MGF (Also known as Pegylated Mechano Growth Factor) is a spliced variant of the IGF-1 (insulin-like growth factor-1). It’s a combination of MGF (Mechano Growth Factor) which plays an integral role post-exercise to help build new muscle and repair damaged muscle. Together with PEG (Polyethylene Glycol) which provides stability for MGF to exert its effects, they are creating an innovative supplement for athletes. Researchers at The University of Vienna in Austria found that MGF was effective in improving athletic performance and treating injuries. [1]

PEG MGF Benefits include:

1. Improved Athletic Performance

2. Increases Lean Muscle Mass

3. Improved Recovery

PEG MGF History

PEG MGF is developed by Swiss Pharmaceutical company Nanox Biotechnology and is considered the best variant of Insulin-like Growth Factor (IGF) for local muscle growth on the market. Research at The Virginia Commonwealth University showed how effective MGF is at eliciting muscle growth. [2]


Mechano Growth Factor (also known as MGF and IGF-1Ec) is a splice variant of IGF-1 and was only discovered in 1996. MGF is produced locally within the muscles, whereas IGF-1 is manufactured in the liver mediated by Growth Hormone (GH).


Using MGF alone poses two restrictions. The first is its inability to travel through the body to other areas of the body and secondly once secreted by the liver it remains in the bloodstream for about 5-7 minutes before it breaks down.


MGF’s role is to increase stem cell count in the muscle, which stimulates muscle growth and recovery and also increase protein synthesis. It is produced naturally as a result of muscle breakdown from resistance training. Research has shown that MGF can increase the weight of muscle fibre by 20 per cent within two weeks, making it more potent at muscle growth than IGF-1. [3]


Furthermore, research at The Royal Free and University College Medical School in London, UK found that in response to exercise and/or damage, MGF is expressed locally and that it activates the muscle stem cell pool and increases the anabolic effects. [4]


This is where the PEGylating of MGF enhances its benefits to be more effective by allowing the MGF molecule to be carried through the bloodstream without breaking down. The Polyethylene Glycol (PEG) attaches itself to the MGF acting as a shell to protect and support it around the body allowing its half-life to change from 5-7 minutes to a few hours.


The function is very similar.


The half-life of MGF is around 5~7 minutes; While the half-life of PEG MGF is a few hours.




  1. Bachl N1, Derman W, Engebretsen L, Goldspink G, Kinzlbauer M, Tschan H, Volpi P, Venter D, Wessner B Therapeutic use of growth factors in the musculoskeletal system in sports-related injuries. on 19 September 2018
  2. Chao Li, Kent Vu, Krystina Hazelgrove, and John F. Kuemmerle Increased IGF-IEc expression and mechano-growth factor production in intestinal muscle of fibrostenotic Crohn’s disease and smooth muscle hypertrophy on 19 September 2018
  3. Vivian Owino Shi Yu Yang  Geoffrey Goldspink Age‐related loss of skeletal muscle function and the inability to express the autocrine form of insulin‐like growth factor‐1 (MGF) in response to mechanical overload on 19 September 2018
  4. G Goldspink and P Jakeman Research on mechano growth factor: its potential for optimising physical training as well as misuse in doping on 19 September 2018
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